Conclusion Altogether, the studies reviewed argue in favor of molecular diagnostics in the context of CMA. The scaling down of diagnostic technology to microchip size will enable allergy medicine to move toward unprecedented standards of care, diagnostic and prognostic detail and personalized treatment. In the future, we will be able to describe patients with CMA from their whey and casein allergen sensitization profiles and map their sensitizing epitopes with a degree of detail that will take testing from the lab to point-of-care settings. These potential breakthroughs should be taken in stride; however, as the degree of precision already achieved is creating such a wealth of information (especially regarding the conformation of cow’s milk allergens) that data management is increasingly complex and clinically relevant material of difficult interpretation. We are still waiting for bedside applications of cow’s milk allergen molecular information. Personalization is not necessarily synonymous with simplification. There will always be a need for the allergy specialist-cum-bioinformatician. A foreseeable risk, therefore, is that of overdiagnosing rather than misdiagnosing CMA and this can only be allayed by the earnest call that we urge on our fellow allergists: investigate and publish in this new frontier of allergy medicine. References and recommended reading Papers of particular interest, published within the annual period of review, have been highlighted as: of special interest of outstanding interest Additional references related to this topic can also be found in the Current World Literature section in this issue (p. 271). 1 Wang J, Sampson HA. Food allergy. J Clin Invest 2011; 121:827–835. 2 Fiocchi A, Brozek J, Schunemann HJ, et al. World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow’s Milk Allergy (DRACMA) guidelines. Pediatr Allergy Immunol 2010; 21 (Suppl 21):1–125.
As the Allergy Week goes on, we read the WAO White Book on Allergy - where it is said that Developing countries as China, India, Indonesia and the like are lacking the WAO resources for learning and treating the Allergic Diseases, including Allergic Asthma and COPD.
What about the Third World - did not mention in that famous Manuscript - but existing?
Is the Allergy Week a fair of classes or medical science applied to all!
@carlosmixares
www.facebook.com/Alergologos. Asma y Alergias
+google Carlos E Mijares
+google Alergologos Centro Medico de Caracas
www.centromedicodecaracas.com.ve
Caracas april 13th, 2015 Venezuela
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