Blog, para el estudio, la publicación, la investigación, la asesoría y la consulta médica,prevención, diagnóstico, tratamiento de las enfermedades alergicas, el asma, la inmunología y la pediatría global en niños y adultos. En Venezuela e internacionalmente.
Blog for the study, publication, research, assesment and the consultancy of medical prevention, diagnosis, treatment of the allergic diseases: asthma,immunology and pediatrics in children and adults in Venezuela and world-wide.
Conclusion
Altogether, the studies reviewed argue in favor of molecular
diagnostics in the context of CMA. The scaling
down of diagnostic technology to microchip size will
enable allergy medicine to move toward unprecedented
standards of care, diagnostic and prognostic detail and
personalized treatment. In the future, we will be able to
describe patients with CMA from their whey and casein
allergen sensitization profiles and map their sensitizing
epitopes with a degree of detail that will take testing from
the lab to point-of-care settings. These potential breakthroughs
should be taken in stride; however, as the
degree of precision already achieved is creating such a
wealth of information (especially regarding the conformation
of cow’s milk allergens) that data management is
increasingly complex and clinically relevant material of
difficult interpretation. We are still waiting for bedside
applications of cow’s milk allergen molecular information.
Personalization is not necessarily synonymous
with simplification. There will always be a need for the
allergy specialist-cum-bioinformatician. A foreseeable
risk, therefore, is that of overdiagnosing rather than
misdiagnosing CMA and this can only be allayed by
the earnest call that we urge on our fellow allergists:
investigate and publish in this new frontier of allergy
medicine.
References and recommended reading
Papers of particular interest, published within the annual period of review, have
been highlighted as:
of special interest
of outstanding interest
Additional references related to this topic can also be found in the Current
World Literature section in this issue (p. 271).
1 Wang J, Sampson HA. Food allergy. J Clin Invest 2011; 121:827–835.
2 Fiocchi A, Brozek J, Schunemann HJ, et al. World Allergy Organization (WAO)
Diagnosis and Rationale for Action against Cow’s Milk Allergy (DRACMA)
guidelines. Pediatr Allergy Immunol 2010; 21 (Suppl 21):1–125.
As the Allergy Week goes on, we read the WAO White Book on Allergy - where it is said that Developing countries as China, India, Indonesia and the like are lacking the WAO resources for learning and treating the Allergic Diseases, including Allergic Asthma and COPD.
What about the Third World - did not mention in that famous Manuscript - but existing?
Is the Allergy Week a fair of classes or medical science applied to all!
Speer, Frederic.: The Allergic tension-fatigue syndrome. Pediatrics Clinics of North America. I:1029, 1 954.
------------------ : The allergic tension-fatigue syndrome in children. International Archives of Allergy. 12:207, 1958.
-------------------: Historical development of allergy of the nervous system. Annals of Allergy 16-14, 1958
ALLERGY AND
BEHAVIOR BY FRED J. KITTLER CHAPTER 44 in
ALLERGY AND
IMMUNOLOGY IN CHILDHOOD in FREDERIC SPEER,M.D. and
.
ROBERT J.
DOCKHORN, MD. University of Kansas and Children’s Mercy Hospital,
Kansas City Kansas & Kansas City Missouri.
1 973. CHARLES C THOMAS
PUBLISHER Illinois. USA.
The child
with behavior problems has been examined from a variety of viewpoints by
pediatricians, psychologists, and psychiatrists. Genetic inheritance,
environment, pampering, sight, and hearing have been studied meticulously. The
ego, interpersonal relations, and the psyche have been dissected in many cases,
and sometimes the dissection bears fruit. Listless, irritable, and
hyperreactive children are brought in vast numbers to psysicians for care, and
the management of their behavior disorders is a leading pediatric concern..
Parents and
teachers are especially concerned when fatigue or irritability affect the
child’s performance in school. On investigation it is often found that the
teacher is not able to hold the child’s attention or interest. Instead the
child may sit and stare dreamily. An abnormally restless, jittery hyperkinetic
child is not only miserable himself but can destroy the study patterns of the
entire classroom. Punishment is a common early reaction, because parents feel
that the child is naughty or trying to get attention
ALLERGY OF
THE NERVOUS SYSTEM by Norman Ward Clein and William G. Crook in THE ALLERGIC
CHILD edited by Frederic Speer, M.D. Harper & Row Publishers
Speer, F.:
The allergic tension-fatigue syndrome. Pediat. Clinic. North
America. I: 1029, 1954.
--------:
The allergic tension – fatigue syndrome in children. Internat. Arch. Allergy.
12:207,
1958
As Fred J.
Kittler wrote: there is growing awareness, among pediatric allergists at least,
of the role allergy plays in causing restlessness and listlessness in
children.This has been especially true
since Speer helped clarify our thinking by coining a new term, the allergic
tension-fatigue syndrome, for an old but previously unnamed allergic syndrome.
Kittler,
cites Speer, 1954 Pediatric clinics of North America
1:1029, 1954. Speer cites himself in Allergy Migraine in Headache 11:63,
1971; Allergic Factors in Migraine en Modern Medicine, Feb 8 p. 100, 1971 and ALLERGIC MIGRAINE in ALLERGY AND IMMUNOLOGY IN CHILDHOOD, 1973.
Clein, Speer, Crook, Dees, Glaser, Rowe, Arce y Calzada en
El síndrome tensión-fatiga del niño como manifestación alérgica en Anales Casa
Salud Valdecilla 16:177, 1955.
Speer , again in Historical development of allergy of the nervous system in Ann. Allergy,
16:14. 1958
Norman W. Clein in COW’S MILK ALLERGY IN INFANTS . Pediatric Clinics of North America. Vol. 1 Number 4, November 1954 References:
Abt. I.A.: Milk as a Food for Infants. Chicago
M. Rec.March 1912: Alvarez W. C. Puzzling Nervous Storm Due to Allergy.
Gastroenterology 7:241, 1946; Speer, Role of Allergy in Infectious Diarrhea of
Infancy. J. Kansas
M. Soc. Nov. 1952. Rowe; Food Allergy. J.Allergy, 1:172, 1938. Cohen.: Milk
Allergy. Am. J. Dis. Child, 38:741, 1929. Ratner, B. Treatment of Milk Allergy
and its Basic Principles. J.A.M.A. 105:934, 1935.
Piness G: Allergic Manifestations in Infancy and Chilhood. Arch
Ped.42:557, 1925.
Speer in 1971 outlined the following diseases to be considered in
differential diagnosis of The Allergic
Tension-Fatigue Syndrome:
Defective vision, defective hearing, mild retardation, malnutrition,
intestinal parasites, lead poisoning, sickle-cell anemia, neuroses, , and
psychosis.Any type of stress, such as
excessive television viewing, family and school problems, and economic
deprivation, may need to be considered. Minimal brain damage from diseases in
infancy or during the mother’s pregnancy or from meningitis may also need to be
thought of.
See five (5) causes of food allergy in children: cow’s milk, wheat, egg, soy,
peanuts and hard nuts.
COW´S MILK ALLERGI IN INFANTS . 206 cases presented by Dr. Norman W. Clein in Pediatrics of
North America. 1954. Copy handed out to me by Dr Speer, personally.
At his
Allergy Clinic, Shwanee- Mission Outlook Street. Kansas
City Kansas. USA
Vincent J.
Fontana, M.D. director of Pediatric Allergy, Bellevue
Hospital , New York, new York, recommended me
to Dr Speer.
Follows a resume of Dr. Clein's paper:
Breast milk is not only the best food, but is also the ideal and natural food for the newborn infant. Few infants are allergic to breast milk. even though the mother may be a highly allergic person. Cow's milk is only a substitute for breast milk and as such may present a relatively high degree of allergenicity.
The majority of babies in this country are presently fed on a cow's milk formula in one form or another and do quite well. There are also a relatively large number who suffer simple colic or become desperately ill as a result of an allergy or sensitivity to milk. For many years it has been hinted that cow's milk may disagree with some babies. Abt, in 1 911 mentioned that some infants have an idiosincrasy to cow's milk which produces "toxic symptoms and injuries to the baby". Piness, in 1 925 called attention to allergic manifestation from food in infants. Pediatric textbooks barely mention milk allergy or refer meagerly to minor gastrointestinal symptoms. Several clinical reports have stressed the intestinal manifestations, omitting or barely mentioning any other type of symptoms. The fact remains that allergty to cow's milk is a common cause of symptoms in many infants. A formula ideal for some babies may be another baby's poison.
A critical clinical analysis of 206 infants allergic to cow's milk reveals a multipicity of ordinary or strange, baffling, mild to serious and often apparently unrelated clinical syndromes. Various prolonged, complicated and expensive diagnostic tests, treatments and even operations have been performed in an effort to relieve these unfortunate infants, because allergy to milk was not suspected as a cause of their symptoms. The type and location of symptoms depend on two factors: (1) the tissue or organ affected and (2) the results of the pathologic mechanism of allergic disease on the particular organ or tissue involved ( edema of mucus membranes, spam of smooth muscle and excess mucus secretion ). If the allergic "trigger"area is in the nose, we expect swelling, stuffiness and excess secretions as well as other local and constitutional symptoms that follow.
Below we show the twelve clinical entities described by Dr. Clein:
Eczema 91
cases
Pylorospasm
78 cases
Colic 65
cases
Diarrhea 47
cases
Very
unhappy all the time, 40 cases
Cough,
croup, choking, gagging, excess mucus in throat 36 cases
Above you can read the current publications of the World Allergy Organization. WAO as presented by a panel of distinguished Allergists / Immunologists but The Allergy Tension - Fatigue Syndrome coined by the American Allergist Frederic Speer in 1.954 is not mentioned, been a breakthrough.
The Global Atlas of Allergic Rhinitis and Chronic Rhinosinusitis by the EAACI in its Chapter 20, says: The concept of Allergic Fatigue is attributed to Melvyn Danzig (1989).
